Just as women’s bodies are so different from one another, their reactions to Clomid vary tremendously. Some women have virtually no side effects. Others do, but they are more frequently related to emotions. Side effects may include mood swings, hot flashes, breast tenderness, thinning of the uterine lining, nausea and vomiting, visual symptoms and abnormal uterine bleeding. About 10 percent of those who use Clomid will have a multiple pregnancy (twins). Clomid can cause hostile fertile mucous and thins the uterine lining in over 30 percent of the women who use it. The hostile mucus kills sperm, and the thin uterine can prevent implantation or cause an early miscarriage.
Most women do not have any symptoms from taking Clomid. Some will have some lower abdominal cramps in the 2nd half of the cycle. Rarely (less than 1-2%) a woman may experience ovarian hyperstimulation syndrome. In this case the ovaries become quite enlarged and grow cysts. If this occurs, the ovaries can cause moderate pelvic pain. There can also be large amounts of fluid secreted into the abdominal cavity. Sometimes the fluid can be so severe that it can cause heart or kidney failure.
Several years ago, there research findings were reported stating that Clomid increased a woman’s chance of getting cervical cancer. The data associated with that study have since been found to be flawed, and many physicians discredit the researchers’ conclusions. However, if you have concerns, talk to your physician about them.
Clomid has been used to induce ovulation for more that thirty years. There is not any evidence that it causes an increase in congenital abnormalities or birth defects in children. It is not associated with an increase in premature labor or in other complications of pregnancy.